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. 2020 Aug 24:734:135094.
doi: 10.1016/j.neulet.2020.135094. Epub 2020 May 26.

Genetic analysis of arylsulfatase A (ARSA) in Chinese patients with Parkinson's disease

Yang Ruan  1 , Ran Zheng  1 , Zhi-Hao Lin  1 , Ting Gao  1 , Nai-Jia Xue  1 , Jin Cao  1 , Jun Tian  1 , Bao-Rong Zhang  2 , Jia-Li Pu  3
Affiliations

Genetic analysis of arylsulfatase A (ARSA) in Chinese patients with Parkinson's disease

Yang Ruan et al. Neurosci Lett. .

Abstract

Recently, the arylsulfatase A (ARSA) variant c.899 T > C (p.L300S) was identified to be segregated with Parkinson's disease (PD) in one family of Japanese descent. And the variant c.1055A > G (p.N352S) of ARSA was reported as a risk reduction factor for PD in a Japanese population. To further investigate the relationship between ARSA and PD, we screened these two loci of the ARSA gene in 407 sporadic PD patients and 471 healthy controls from a Chinese Han population. However, we did not detect the ARSA p.L300S variant in either PD patients or healthy controls. Moreover, in case-control association analysis, the p.N325S variant showed no significant association with PD. Therefore, these results suggested that these ARSA variants may not be common genetic factors for sporadic PD in Chinese Han population.

Keywords: ARSA; Genetics; Parkinson’s disease.

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