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Comment
. 2020 Aug;41(8):501-503.
doi: 10.1016/j.tips.2020.05.002. Epub 2020 May 20.

Overwhelming COVID-19 Clinical Trials: Call for Prospective Meta-Analyses

Zhongren Ma  1 , Jiaye Liu  2 , Qiuwei Pan  3
Affiliations
Comment

Overwhelming COVID-19 Clinical Trials: Call for Prospective Meta-Analyses

Zhongren Ma et al. Trends Pharmacol Sci. 2020 Aug.
No abstract available

Keywords: COVID-19; clinical trial; prospective meta-analysis.

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Figures

Figure 1
Figure 1
A Workflow for Conducting Prospective Meta-Analyses (PMAs) in the Context of Overwhelming Coronavirus 2019 (COVID-19) Clinical Trials. Prospectively forming a collaboration or consortium of PMA to pool multiple eligible studies that aim to address the same clinical question will likely generate reliable data for guiding clinical management and regulatory decision-making. This will not affect the individual studies and will not prevent the publication of the results of those individual studies.
See this image and copyright information in PMC

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References

    1. Lythgoe M.P., Middleton P. Ongoing clinical trials for the management of the COVID-19 pandemic. Trends Pharmacol. Sci. 2020;41:363–382. - PMC - PubMed
    1. Wang M. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269–271. - PMC - PubMed
    1. Dao Thi V.L. Sofosbuvir inhibits hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. 2016;150:82–85. - PubMed
    1. Kamar N. Direct-acting antiviral therapy for hepatitis E virus? Lancet Gastroenterol. Hepatol. 2017;2:154–155. - PubMed
    1. Cornberg M. Efficacy and safety of sofosbuvir monotherapy in patients with chronic hepatitis E-The HepNet SofE pilot study. J. Hepatol. 2019;70:E129–E130. - PubMed