Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease

L M P Wesselman^#^{1

2}, D Melo van Lent^#^{3

4

5

6}, A Schröder³, O van de Rest⁷, O Peters^{8

9}, F Menne⁹, M Fuentes⁹, J Priller^{8

10}, E J Spruth^{8

10}, S Altenstein¹⁰, A Schneider^{3

11}, K Fließbach^{3

11}, S Roeske³, S Wolfsgruber^{3

11}, L Kleineidam^{3

11}, A Spottke^{3

12}, V Pross¹³, J Wiltfang^{14

15}, R Vukovich^{14

15}, A K Schild^{3

16}, E Düzel^{17

18}, C D Metzger^{17

18

19}, W Glanz¹⁷, K Buerger^{20

21}, D Janowitz²¹, R Perneczky^{20

22

23

24}, M Tatò²⁰, S Teipel^{25

26}, I Kilimann^{25

26}, C Laske^{27

28}, M Buchmann^{27

28}, A Ramirez¹⁶, S A M Sikkes^{29

30}, F Jessen^{3

16}, W M van der Flier^{29

31}, M Wagner^{3

11}

Affiliations

¹ German Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. l.wesselman@amsterdamumc.nl.
² Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. l.wesselman@amsterdamumc.nl.
³ German Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
⁴ The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health, San Antonio, TX, USA.
⁵ Department of Neurology, Boston University, Boston, MA, USA.
⁶ The Framingham Heart Study, Framingham, MA, USA.
⁷ Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
⁸ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
⁹ Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203, Berlin, Germany.
¹⁰ Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.
¹¹ Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
¹² Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
¹³ Study Center Bonn, Medical Faculty, Venusberg-Campus 1, 53127, Bonn, Germany.
¹⁴ German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
¹⁵ Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075, Goettingen , Germany.
¹⁶ Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924, Cologne, Germany.
¹⁷ German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
¹⁸ Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.
¹⁹ Department of Psychiatry and Psychotherapy, Otto-Von-Guericke University, Magdeburg, Germany.
²⁰ German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
²¹ Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
²² Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
²³ Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.
²⁴ Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK.
²⁵ German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
²⁶ Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.
²⁷ German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
²⁸ Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
²⁹ Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
³⁰ Clinical Developmental Psychology and Clinical Neuropsychology, Faculty of Behavioural and Movement Sciences (FGB), Vrije University Amsterdam, Amsterdam, The Netherlands.
³¹ Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

^# Contributed equally.

PMID: 32472387
PMCID: PMC7900077
DOI: 10.1007/s00394-020-02257-6

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease

L M P Wesselman et al. Eur J Nutr. 2021 Mar.

. 2021 Mar;60(2):849-860.

doi: 10.1007/s00394-020-02257-6. Epub 2020 May 29.

Authors

Affiliations

¹ German Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. l.wesselman@amsterdamumc.nl.
² Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. l.wesselman@amsterdamumc.nl.
³ German Center for Neurodegenerative Disorders (DZNE), Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
⁴ The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health, San Antonio, TX, USA.
⁵ Department of Neurology, Boston University, Boston, MA, USA.
⁶ The Framingham Heart Study, Framingham, MA, USA.
⁷ Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
⁸ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
⁹ Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203, Berlin, Germany.
¹⁰ Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.
¹¹ Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
¹² Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
¹³ Study Center Bonn, Medical Faculty, Venusberg-Campus 1, 53127, Bonn, Germany.
¹⁴ German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
¹⁵ Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075, Goettingen , Germany.
¹⁶ Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener Strasse 62, 50924, Cologne, Germany.
¹⁷ German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
¹⁸ Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.
¹⁹ Department of Psychiatry and Psychotherapy, Otto-Von-Guericke University, Magdeburg, Germany.
²⁰ German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
²¹ Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Strasse 17, 81377, Munich, Germany.
²² Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
²³ Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.
²⁴ Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK.
²⁵ German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
²⁶ Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.
²⁷ German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
²⁸ Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
²⁹ Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
³⁰ Clinical Developmental Psychology and Clinical Neuropsychology, Faculty of Behavioural and Movement Sciences (FGB), Vrije University Amsterdam, Amsterdam, The Netherlands.
³¹ Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

^# Contributed equally.

PMID: 32472387
PMCID: PMC7900077
DOI: 10.1007/s00394-020-02257-6

Abstract

Purpose: To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.

Methods: Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer's disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components.

Results: In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The 'alcoholic beverages' PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant.

Conclusion: In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

Keywords: Cognition; Dementia; Dietary patterns; MIND diet; Mediterranean diet.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease

Affiliations

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease

Authors

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Abstract

Conflict of interest statement

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