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Review
. 2020 Nov;92(11):2429-2439.
doi: 10.1002/jmv.26100. Epub 2020 Jun 29.

The long-standing history of Corynebacterium parvum, immunity, and viruses

Beniamino Palmieri  1   2 , Maria Vadalà  2 , Luca Roncati  3 , Andrea Garelli  4 , Francesco Scandone  5 , Moreno Bondi  6 , Claudio Cermelli  7
Affiliations
Review

The long-standing history of Corynebacterium parvum, immunity, and viruses

Beniamino Palmieri et al. J Med Virol. 2020 Nov.

Abstract

We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD-19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.

Keywords: C. parvum; coronavirus; immune responses; immunomodulation; innate immunity.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

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