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. 1988 Apr;5(4):236-7.
doi: 10.1023/a:1015945830309.

Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride

L Schjelderup  1 , M R Kozlowski, A Weissman, A J Aasen
Affiliations

Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride

L Schjelderup et al. Pharm Res. 1988 Apr.

Abstract

The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.

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