SARS-CoV-2: The viral shedding vs infectivity dilemma

doi:10.1016/j.idh.2020.05.002

. 2020 Aug;25(3):210-215.

doi: 10.1016/j.idh.2020.05.002. Epub 2020 May 20.

SARS-CoV-2: The viral shedding vs infectivity dilemma

Arabella Widders¹, Alex Broom², Jennifer Broom³

Affiliations

¹ Department of Medicine, Sunshine Coast Hospital and Health Service, Birtinya, 4575, Queensland, Australia. Electronic address: arabella.widders@health.qld.gov.au.
² School of Social and Political Sciences, The University of Sydney, Sydney, 2006, New South Wales, Australia.
³ Sunshine Coast Health Institute, Birtinya, 4575, Queensland, Australia; School of Medicine, The University of Queensland, Brisbane, 4072, Queensland, Australia.

PMID: 32473952
PMCID: PMC7237903
DOI: 10.1016/j.idh.2020.05.002

SARS-CoV-2: The viral shedding vs infectivity dilemma

Arabella Widders et al. Infect Dis Health. 2020 Aug.

. 2020 Aug;25(3):210-215.

doi: 10.1016/j.idh.2020.05.002. Epub 2020 May 20.

Authors

Arabella Widders¹, Alex Broom², Jennifer Broom³

Affiliations

¹ Department of Medicine, Sunshine Coast Hospital and Health Service, Birtinya, 4575, Queensland, Australia. Electronic address: arabella.widders@health.qld.gov.au.
² School of Social and Political Sciences, The University of Sydney, Sydney, 2006, New South Wales, Australia.
³ Sunshine Coast Health Institute, Birtinya, 4575, Queensland, Australia; School of Medicine, The University of Queensland, Brisbane, 4072, Queensland, Australia.

PMID: 32473952
PMCID: PMC7237903
DOI: 10.1016/j.idh.2020.05.002

Abstract

Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over four million people worldwide. There are multiple reports of prolonged viral shedding in people infected with SARS-CoV-2 but the presence of viral RNA on a test does not necessarily correlate with infectivity. The duration of quarantine required after clinical recovery to definitively prevent transmission is therefore uncertain. In addition, asymptomatic and presymptomatic transmission may occur, and infectivity may be highest early after onset of symptoms, meaning that contact tracing, isolation of exposed individuals and social distancing are essential public health measures to prevent further spread. This review aimed to summarise the evidence around viral shedding vs infectivity of SARS-CoV-2.

Keywords: COVID-19; Public health; SARS-CoV-2; Transmission; Virus shedding.

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References

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[1] Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020 Apr 24 doi: 10.1016/S1473-3099(20)30120-1. [Internet] - DOI - PMC - PubMed

[2] Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020 Apr 24 doi: 10.1016/S1473-3099(20)30120-1. [Internet] - DOI - PMC - PubMed

[3] Wan Y., Shang J., Graham R., Baric R.S., Li F. In: Gallagher T., editor. vol. 94. J Virol; 2020 Mar 17. p. e00127. (Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus). [Internet] (7)20. - DOI - PMC - PubMed

[4] Wan Y., Shang J., Graham R., Baric R.S., Li F. In: Gallagher T., editor. vol. 94. J Virol; 2020 Mar 17. p. e00127. (Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus). [Internet] (7)20. - DOI - PMC - PubMed

[5] World Health Organisation. Coronavirus Disease 2019 (COVID-19): Situation Report-51 [Internet]. [cited 2020 Mar 18]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2....

[6] World Health Organisation. Coronavirus Disease 2019 (COVID-19): Situation Report-51 [Internet]. [cited 2020 Mar 18]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2....

[7] The Department of Health Coronavirus disease 2019 (COVID-19) 2020. https://www1.health.gov.au/internet/main/publishing.nsf/Content/cdna-son... [Internet][cited 2020 Mar 26]. Available from:

[8] The Department of Health Coronavirus disease 2019 (COVID-19) 2020. https://www1.health.gov.au/internet/main/publishing.nsf/Content/cdna-son... [Internet][cited 2020 Mar 26]. Available from:

[9] Wölfel R., Corman V.M., Guggemos W., Seilmaier M., Zange S., Müller M.A. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020 doi: 10.1038/s41586-020-2196-x. [Internet] - DOI - PubMed

[10] Wölfel R., Corman V.M., Guggemos W., Seilmaier M., Zange S., Müller M.A. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020 doi: 10.1038/s41586-020-2196-x. [Internet] - DOI - PubMed

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SARS-CoV-2: The viral shedding vs infectivity dilemma

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SARS-CoV-2: The viral shedding vs infectivity dilemma

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