Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Oct;48(5):783-790.
doi: 10.1007/s15010-020-01454-z. Epub 2020 May 30.

Abiotrophia defectiva as a cause of infective endocarditis with embolic complications in children

Seung Ha Song  1 , Bin Ahn  1 , Eun Hwa Choi  1   2 , Seung-Pyo Lee  3 , Eun Young Cho  4 , Eun Jung Bae  1   2 , Sang Yun Lee  1   2 , Mi Kyoung Song  1 , Woong Han Kim  5 , Geena Kim  4 , Taek Soo Kim  6 , Mi Seon Han  7   8
Affiliations
Case Reports

Abiotrophia defectiva as a cause of infective endocarditis with embolic complications in children

Seung Ha Song et al. Infection. 2020 Oct.

Abstract

Abiotrophia defectiva is a rare pathogen of infective endocarditis (IE) but is frequently involved in embolic complication and valvular dysfunction. IE caused by A. defectiva in children is poorly studied. This study reports four cases of A. defectiva IE in children and reviews previously reported five pediatric cases of A. defectiva IE. Most of the patients presented with a subacute course, with prolonged fever or atypical symptoms. Eight patients had embolic complications at presentation. All nine children were treated with combination antimicrobial therapy and six of them received surgical intervention. All patients recovered well without relapse. A. defectiva should be considered in children with infective endocarditis, especially in those with atypical presentations. As complications are frequent and more than half of the patients need surgical treatment, prompt diagnosis along with appropriate treatment is necessary.

Keywords: Abiotrophia; Children; Embolism; Infective endocarditis.

PubMed Disclaimer

References

    1. Bouvet A. Human endocarditis due to nutritionally variant streptococci: Streptococcus adjacens and Streptococcus defectivus. Eur Heart J. 1995;16:24–7. - DOI
    1. Alberti MO, Hindler JA, Humphries RM. Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans. Antimicrob Agents Chemother. 2015;60:1411–20. - DOI
    1. Kawamura Y, Hou XG, Sultana F, Liu S, Yamamoto H, Ezaki T. Transfer of Streptococcus adjacens and Streptococcus defectivus to Abiotrophia gen. nov. as Abiotrophia adiacens comb. Nov. and Abiotrophia defectiva comb. nov., respectively. Int J Syst Bacteriol. 1995;45:798–803. - PubMed
    1. Brouqui P, Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev. 2001;14:177–207. - PubMed - PMC
    1. Christensen JJ, Facklam RR. Granulicatella and Abiotrophia species from human clinical specimens. J Clin Microbiol. 2001;39:3520–3. - PubMed - PMC

Publication types

Substances

Supplementary concepts

LinkOut - more resources