Non-tuberculous mycobacterial pulmonary disease: an Italian National survey
- PMID: 32476876
- PMCID: PMC7170062
- DOI: 10.36141/svdld.v35i1.6979
Non-tuberculous mycobacterial pulmonary disease: an Italian National survey
Abstract
The incidence of non-tuberculous mycobacteria (NTM) infection is increasing in Europe. However, a picture of Italian epidemiology and clinical practice is missing. We performed a national Italian survey involving 42 respiratory medicine departments. The NTM species more frequently isolated were Mycobacterium avium complex, followed by M. xenopi and M. kansasii. Patients with NTM were more frequently female (57%), and over 60 years of age, with bronchiectasis and COPD as main comorbidities. Bronchoscopic samples were widely used in the diagnostic phase. Of all patients with NTM, 73% met the criteria for NTM pulmonary disease. Despite strong adherence to the guidelines, physicians found significant difficulties related to pharmacological adverse events, patients' compliance and poor outcomes. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 21-25).
Keywords: epidemiology; non-tuberculous mycobacterial pulmonary disease; survey.
Copyright: © 2018.
Figures
Similar articles
-
Clinical relevance of pulmonary non-tuberculous mycobacterial isolates in three reference centres in Belgium: a multicentre retrospective analysis.BMC Infect Dis. 2019 Dec 17;19(1):1061. doi: 10.1186/s12879-019-4683-y. BMC Infect Dis. 2019. PMID: 31847834 Free PMC article.
-
[Evaluation of the distribution of non-tuberculous mycobacteria strains isolated in National Tuberculosis Reference Laboratory in 2009-2010, Turkey].Mikrobiyol Bul. 2012 Oct;46(4):560-7. Mikrobiyol Bul. 2012. PMID: 23188570 Turkish.
-
[Treatment of non-tuberculous pulmonary mycobacteriosis].Kekkaku. 2006 Jan;81(1):35-50. Kekkaku. 2006. PMID: 16479999 Review. Japanese.
-
[Non-tuberculous mycobacteriosis. What has been coming out].Kekkaku. 2011 Feb;86(2):113-25. Kekkaku. 2011. PMID: 21404655 Japanese.
-
Pulmonary Disease Caused by Non-Tuberculous Mycobacteria.Respiration. 2016;91(5):386-402. doi: 10.1159/000445906. Epub 2016 May 21. Respiration. 2016. PMID: 27207809 Review.
Cited by
-
Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine.Infection. 2024 Jun;52(3):737-765. doi: 10.1007/s15010-024-02183-3. Epub 2024 Feb 8. Infection. 2024. PMID: 38329686 Free PMC article. Review.
-
Exploring Potential COPD Immunosuppression Pathways Causing Increased Susceptibility for MAC Infections among COPD Patients.Clin Pract. 2021 Sep 9;11(3):619-630. doi: 10.3390/clinpract11030077. Clin Pract. 2021. PMID: 34563006 Free PMC article. Review.
-
Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens.J Med Chem. 2024 Nov 14;67(21):19143-19164. doi: 10.1021/acs.jmedchem.4c01594. Epub 2024 Oct 28. J Med Chem. 2024. PMID: 39468773 Free PMC article.
-
Prescription habits and drugs accessibility for the treatment of non-tuberculous mycobacteria infections in Italy: a multicentric survey from the IRENE study group.Infection. 2025 Feb;53(1):383-392. doi: 10.1007/s15010-024-02390-y. Epub 2024 Sep 20. Infection. 2025. PMID: 39302627 Free PMC article.
References
-
- Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, et al. An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases. Am J Respir Crit Care Med. 2007 Feb 15;175(4):367–416. - PubMed
-
- Larsson L-O, Polverino E, Hoefsloot W, et al. Pulmonary disease by non-tuberculous mycobacteria - clinical management, unmet needs and future perspectives. Expert Rev Respir Med. 2017 Oct;10:1–13. - PubMed
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous