Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018;35(4):294-298.
doi: 10.36141/svdld.v35i4.6757. Epub 2020 Mar 9.

Comparison of serum interleukin-10 level of fungal exposure among patients with pulmonary sarcoidosis and healthy people

Seyed Ali Alavi Foumani  1 , Siamak Geranmayeh  2 , Azita Tangestani Nejad  1 , Aydin Pour Kazemi  3 , Ehsan Kazem Nejad Leili  4 , Alireza Jafari  5 , Mehrzad Amooei Khanabbasi  1
Affiliations

Comparison of serum interleukin-10 level of fungal exposure among patients with pulmonary sarcoidosis and healthy people

Seyed Ali Alavi Foumani et al. Sarcoidosis Vasc Diffuse Lung Dis. 2018.

Abstract

Introduction: Sarcoidosis is a chronic systemic inflammatory disease with unknown etiology. Fungal exposure has been assumed as one of many possible causes of the disease. The prevalence of sarcoidosis is likely to be higher in the Northern Iran compared with other regions. Environmental studies have shown higher levels of fungal spores in the air of this area. Some studies have shown that fungal exposure in patients with sarcoidosis is associated with decreased levels of interleukin-10 (IL-10) serum levels. The aim of present study was comparison of the serum levels of IL-10 in patients with pulmonary sarcoidosis and healthy people. Objectives and Methods: In this current analytical, cross-sectional study, 40 patients with pulmonary sarcoidosis compared with 34 healthy individuals as a control group, who had been visited in a pulmonary referral clinic in Rasht (Guilan-Iran). Demographic data were collected by a questionnaire. Serum IL-10 levels were measured by ELISA kit. The data were analyzed by using the SPSS software (version 19). Results: The mean concentration of IL-10 serum levels were reported 10.96±9.48 pg/ml-1 and 3.77±1.47 pg/ml-1 among the patients with pulmonary sarcoidosis and healthy individuals, respectively. The significance difference was demonstrated between patients with pulmonary sarcoidosis and control group (p<0.0001). The IL-10 showed a significant difference between the patients older than 40 and those younger than 40. In statistical analysis, 4.75 pg.ml-1 was considered the cutoff point to separate patients and control group. Conclusion: The results showed that IL-10 was greater among patients who diagnosed as pulmonary sarcoidosis. There was a contrary opinion of the expectations for the role of fungal exposure as a possible cause of greater prevalence of sarcoidosis in Northern Iran. Age and stage of disease showed a significant relationship with the IL-10 serum level and requires further investigation. IL-10 might be a possible predictor of sarcoidosis along with other factors. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 294-298).

Keywords: IL-10; blood serum; fungal exposure; pulmonary sarcoidoses.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
IL-10 Box Plat in Two Groups
Fig. 2.
Fig. 2.
Error Bar of 95% for IL-10 in Two Groups
Fig. 3.
Fig. 3.
ROC Curve of IL-10 Predictor Level
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Iannuzzi MC, RB TA. Sarcoidosis. N Engl J Med. 2007;21:53–65. - PubMed
    1. Baughman RP, Culver DA, Judson MA. A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med. 2011;183(5):573–81. - PMC - PubMed
    1. Terčelj M, Stopinšek S, Ihan A, Salobir B, Simčič S, Rylander R. Fungal exposure and low levels of IL-10 in patients with sarcoidosis. Pulm Med. 2014;2014 - PMC - PubMed
    1. Alavi A, Akhoundzadeh N, Karkan MF. Sarcoidosis, a report from Guilan (an Iranian Northen province)(2001-09) Sarcoidosis Vasc Diffuse Lung Dis. 2015;31(4):282–8. - PubMed
    1. Spagnolo P. Sarcoidosis: a critical review of history and milestones. Clin Rev Allergy Immunol. 2015;49(1):1–5. - PubMed

LinkOut - more resources