Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018;35(4):327-332.
doi: 10.36141/svdld.v35i4.7058. Epub 2020 Mar 9.

Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study

Mickael Catinon  1   2   3 , Catherine Cavalin  2   4   5 , Cécile Chemarin  1   3 , Stéphane Rio  1 , Elisabeth Roux  1 , Mathieu Pecquet  1 , Anne-Sophie Blanchet  1 , Sylvie Vuillermoz  1 , Christophe Pison  6 , François Arbib  6 , Vincent Bonneterre  7 , Dominique Valeyre  8 , Olivia Freynet  8 , Jean-François Mornex  9   10 , Yves Pacheco  11 , Nathalie Freymond  11 , Françoise Thivolet  12 , Marianne Kambouchner  13 , Jean-François Bernaudin  8   14 , Audrey Nathalizio  15 , Pierre Pradat  16 , Paul-André Rosental  2 , Michel Vincent  1   2   3
Affiliations

Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study

Mickael Catinon et al. Sarcoidosis Vasc Diffuse Lung Dis. 2018.

Abstract

Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 327-332).

Keywords: bronchoalveolar lavage; dust exposure; sarcoidosis.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Flow chart showing how the dust questionnaire was scored
Fig. 2.
Fig. 2.
Mineral content in sarcoidosis patients (black dots) and healthy volunteers (grey dots). Ti comp=titanium compound, Cr= chromium, Al=aluminium
See this image and copyright information in PMC

References

    1. Gentry JT, Nitowsky HM, Michael M. Studies on the epidemiology of sarcoidosis in the United States: the relationship to soil areas and to urban-rural residence. J Clin Invest. 1955 Dec;34(12):1839–56. - PMC - PubMed
    1. Rafnsson V, Ingimarsson O, Hjalmarsson I, Gunnarsdottir H. Association between exposure to crystalline silica and risk of sarcoidosis. Occup Environ Med. 1998 Oct;55(10):657–60. - PMC - PubMed
    1. Vincent M, Lievre M. [Sarcoidosis and pulmonary dust exposure, a plausible pathogenic link] Rev Mal Respir. 2002 Feb;19(1):103–4. - PubMed
    1. Heffner DK. The cause of sarcoidosis: the Centurial enigma solved. Ann Diagn Pathol. 2007 Apr;11(2):142–52. - PubMed
    1. Hunninghake GW, Costabel U, Ando M, et al. ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis. 1999 Sep;16(2):149–73. - PubMed

LinkOut - more resources