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. 2020 May 14;33(3):e100192.
doi: 10.1136/gpsych-2020-100192. eCollection 2020.

Association of the HTR2C-759C/T polymorphism and antipsychotic-induced weight gain: a meta-analysis

Yan Chen  1 , Yewei Wang  1 , Xinyu Fang  1 , Yi Zhang  1 , Lisheng Song  1 , Chen Zhang  1
Affiliations

Association of the HTR2C-759C/T polymorphism and antipsychotic-induced weight gain: a meta-analysis

Yan Chen et al. Gen Psychiatr. .

Abstract

Background: Antipsychotic-induced weight gain (AIWG) is a crucial factor for the medication cessation of patients with schizophrenia. Multiple studies have shown that the functional polymorphism -759 C/T (rs3813929) in the HTR2C promoter region could possibly be correlated with AIWG.

Aim: To evaluate the genetic association of the HTR2C-759C/T polymorphism and AIWG in patients with schizophrenia with antipsychotic drugs (APDs) administration.

Methods: Eligible studies were identified by searching the following databases: PubMed, Embase, Web of Science, China Nation Knowledge Infrastructure (CNKI), VIP, Wanfang Data, Chinese Biomedical Literature Database (CBM) and the Airiti Library. The quality of studies was evaluated based on the Newcastle-Ottawa Scale. The pooled OR and 95% CI were calculated for the dominant (CT/TT/T vs CC/C) mode, and subgroup analyses were performed based on ethnicity, antipsychotic medication and gender; all statistical analyses were performed using the statistical software STATA V.12.0.

Result: A total of 17 studies with 3170 patients with schizophrenia were included in our meta-analysis. The result of the meta-analysis has shown that the association between the -759 C/T polymorphism and AIWG is statistically significant (OR 0.34, 95% CI: 0.20 to 0.57, z=4.11, p<0.001). The subgroup analyses revealed significant correlations between the -759 C/T polymorphism and AIWG in the Caucasian population (OR 0.33, 95% CI: 0.14 to 0.77, z=2.55, p=0.011), the Asian population (OR 0.31, 95% CI: 0.18 to 0.52, z=4.46, p<0.001), the patients with APDs administration (CT/TT/T vs CC/C: OR 0.63, 95% CI: 0.40 to 1.00, z=1.97, p=0.049) and the patients with atypical antipsychotic drug administration (CT/TT/T vs CC/C: OR 0.21, 95% CI: 0.09 to 0.47, z=3.83, p<0.001). The sensitivity analysis showed that the results were stable. Begg's test (after correction z=1.07, p=0.287) and Egger's test (t=-2.41, p=0.029) show that the included articles have no significant publication bias.

Conclusion: There is a significant genetic association between HTR2C-759C/T and AIWG, and patients with T allele are less likely to have AIWG.

Keywords: meta-analysis as topic; schizophrenia.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Flowchart of the search process
Figure 2
Figure 2
Meta-analysis forest plot of the genetic correlation of HTR2C-759C/T polymorphism and antipsychotic-induced weight gain (subgroup analysis based on ethnicity).
Figure 3
Figure 3
Meta-analysis forest plot of the genetic association between HTR2C-759C/T polymorphism and antipsychotic-induced weight gain (subgroup analysis based on the type of antipsychotic medication). AAP, atypical antipsychotic drug; APD, antipsychotic drug.
Figure 4
Figure 4
Sensitivity analysis.
Figure 5
Figure 5
Begg’s funnel plot.
See this image and copyright information in PMC

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