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Review
. 2020 Jul:34:101512.
doi: 10.1016/j.redox.2020.101512. Epub 2020 May 23.

NADPH oxidases: Current aspects and tools

Katrin Schröder  1
Affiliations
Review

NADPH oxidases: Current aspects and tools

Katrin Schröder. Redox Biol. 2020 Jul.

Abstract

Reactive oxygen species (ROS) have been shown or at least suggested to play an essential role for cellular signaling as second messengers. NADPH oxidases represent a source of controlled ROS formation. Accordingly, understanding the role of individual NADPH oxidases bears potential to interfere with intracellular signaling cascades without disturbing the signaling itself. Many tools have been developed to study or inhibit the functions and roles of the NADPH oxidases. This short review summarizes diseases, potentially associated with NADPH oxidases, genetically modified animals, and inhibitors.

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Conflict of interest statement

Declaration of competing interest The author declares no conflict of interest.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Scheme and classification of the members of the NADPH oxidase family. NADPH oxidases can be classified into three groups according to their mode of activation. Nox1-3 are activatable via the assembly of cytosolic subunits and produce •O2ˉ. Nox5 and the Duoxes can be activated by Ca2+ and produce •O2ˉ or H2O2. The single member of group three is Nox4, which produces H2O2 in a direct manner independent from cytosolic subunits. Further explanations can be found in the text.
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