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. 2020 May 29;99(22):e20457.
doi: 10.1097/MD.0000000000020457.

Effects of ozone for treating chronically refractory wounds and ulcers: A protocol for systematic review and meta-analysis of randomized clinical trials

Qing Wen  1 , Dongying Liu, Xian Wang, Yanli Zhang, Song Fang, Xianliang Qiu, Qiu Chen
Affiliations

Effects of ozone for treating chronically refractory wounds and ulcers: A protocol for systematic review and meta-analysis of randomized clinical trials

Qing Wen et al. Medicine (Baltimore). .

Abstract

Background: The prevalence of chronically refractory wounds and ulcers is growing rapidly. However, the treatment options are not completely effective. Ozone has been demonstrated as being useful in promoting wound healing as well as adverse events in individual studies. Consequently, it is necessary to conduct a meta-analysis of high-quality trials to find out whether ozone therapy is effective and safe in these chronic wounds.

Methods: We will search the Cochrane Library, PubMed, the Web of Science, Embase, CBM, and the Chinese Clinical Registry website without restriction on language, date, or study setting. Randomized controlled trials of ozone therapy for chronical wounds or ulcers will be retrieved in diverse databases from inception to May 2020. The primary outcome of the meta-analysis is the proportion of participants with completely healed wounds; time to achieve complete ulcer healing; change in wound size. The secondary outcomes include the incidence of adverse events, amputation, quality of life, length of hospital stay, and cost. Two reviewers will adopt the Cochrane Collaboration's risk of bias tool to assess the randomized controlled trials and all relevant data will be analyzed by utilizing the Review Manager software V5.3.0.

Results: This study will offer a high-quality synthesis of the effectiveness and safety of ozone for treating chronically refractory wounds and ulcers.

Conclusion: This systematic review and meta-analysis will find out the available evidence to assess whether ozone therapy is beneficial to wound healing and side effects, producing evidence reference for clinical practice on the treatment of wound care.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram of the study selection. RCT = randomized controlled trial.
See this image and copyright information in PMC

References

    1. Wysocki AB. Wound fluids and the pathogenesis of chronic wounds. J Wound Ostomy Continence Nurs 1996;23:283–90. - PubMed
    1. Nunan R, Harding KG, Martin P. Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Dis Model Mech 2014;7:1205–13. - PMC - PubMed
    1. Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair Regen 1994;2:165–70. - PubMed
    1. Jull AB, Cullum N, Dumville JC, et al. Honey as a topical treatment for wounds (review). Cochrane Database Syst Rev 2015;CD005083. - PMC - PubMed
    1. Gupta A. A review of the use of maggots in wound therapy. Ann Plast Surg 2008;60:224–7. - PubMed

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