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Case Reports
. 2020 Nov-Dec;95(6):721-723.
doi: 10.1016/j.abd.2019.07.010. Epub 2020 Mar 19.

Primary hypothyroidism with exuberant dermatological manifestations

Thadeu Santos Silva  1 , Gustavo Baptista de Almeida Faro  2 , Márcia Gabrielle Bonfim Cortes  2 , Vitória Regina Pedreira de Almeida Rego  2
Affiliations
Case Reports

Primary hypothyroidism with exuberant dermatological manifestations

Thadeu Santos Silva et al. An Bras Dermatol. 2020 Nov-Dec.

Abstract

Thyroid hormone has effects on the skin. Patients with hypothyroidism have changes such as dry, scaly and rough skin. Increase carotene in the dermis becomes a yellowish tone to the skin of the patient with hypothyroidism. There is an increase in capillary cycle (anagen phase) and nail growth and a reduction in eccrine gland secretion. It is a case of primary hypothyroidism with nail manifestations associated with dermatologic disorders and successful treatment with levothyroxine. Receptors for thyroid hormone have already been found in keratinocytes, fibroblasts, hair follicles and sebaceous glands. Genes responsive to thyroid hormones and elements of the hypothalamic-pituitary-thyroid axis were identified on the skin. This report highlights the importance of cutaneous manifestations as markers of thyroid disease.

Keywords: Hypothyroidism; Thyroid diseases; Thyroid gland; Thyroid hormones; Thyroxine.

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Figures

Figure 1
Figure 1
Dystrophic fingernails in quirodactyls.
Figure 2
Figure 2
Dystrophic fingernails on toes and malleolar edema.
Figure 3
Figure 3
Desquamation and nail pigmentation in the hallux.
Figure 4
Figure 4
Myxedematous facies, pallor and periorbital edema.
Figure 5
Figure 5
Significant improvement of lesions after 30 days of hormone replacement.
See this image and copyright information in PMC

References

    1. Safer J.D. Thyroid hormone action on skin. Dermatol Endocrinol. 2011;3:211–215. - PMC - PubMed
    1. Billoni N., Buan B., Gautier B., Gaillard O., Mahé Y.F., Bernard B.A. Thyroid hormone receptor beta1 is expressed in the human hair follicle. Br J Dermatol. 2000;142:645–652. - PubMed
    1. Cianfarani F., Baldini E., Cavalli A., Marchioni E., Lembo L., Teson M. TSH receptor and thyroid-specific gene expression in human skin. J Invest Dermatol. 2010;130:93–101. - PubMed
    1. Fernando R., Lu Y., Atkins S.J., Mester T., Branham K., Smith T.J. Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE. J Clin Endocrinol Metab. 2014;99:e1236–e1244. - PMC - PubMed
    1. Taguchi T. Brittle nails and hair loss in hypothyroidism. N Engl J Med. 2018;379:1363. - PubMed

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