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Comment
. 2020 Jun;10(6):762-764.
doi: 10.1158/2159-8290.CD-20-0359.

Chemotherapy and Tumor Evolution Shape Pancreatic Cancer Recurrence after Resection

Filip Bednar  1   2 , Marina Pasca di Magliano  3   2   4
Affiliations
Comment

Chemotherapy and Tumor Evolution Shape Pancreatic Cancer Recurrence after Resection

Filip Bednar et al. Cancer Discov. 2020 Jun.

Abstract

Most patients with pancreatic cancer who undergo curative resection and systemic chemotherapy still relapse with local or systemic recurrence. In this issue, Sakamoto and colleagues use advanced genomic tools to investigate the evolutionary origins of pancreatic cancer recurrence and discover an increased mutational burden that might be promoted by therapeutic intervention and might provide an opportunity for therapeutic intervention.See related article by Sakamoto et al., p. 792.

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Comment on

  • The Evolutionary Origins of Recurrent Pancreatic Cancer.
    Sakamoto H, Attiyeh MA, Gerold JM, Makohon-Moore AP, Hayashi A, Hong J, Kappagantula R, Zhang L, Melchor JP, Reiter JG, Heyde A, Bielski CM, Penson AV, Gönen M, Chakravarty D, O'Reilly EM, Wood LD, Hruban RH, Nowak MA, Socci ND, Taylor BS, Iacobuzio-Donahue CA. Sakamoto H, et al. Cancer Discov. 2020 Jun;10(6):792-805. doi: 10.1158/2159-8290.CD-19-1508. Epub 2020 Mar 19. Cancer Discov. 2020. PMID: 32193223 Free PMC article.

References

    1. Sakamoto H, Attiyeh MA, Gerold JM, Makohon-Moore AP, Hayashi A, Hong J, et al. The evolutionary origins of recurrent pancreatic cancer. Cancer Discov. 2020;10:792–805.
    1. Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, et al. Tracking the evolution of non-small-cell lung cancer. N Engl J Med. 2017;376:2109–21.
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    1. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010;467:1114–7.

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