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Published Erratum
. 2020 Jul 1;205(1):300-301.
doi: 10.4049/jimmunol.2000441. Epub 2020 Jun 1.

Correction: Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation

Zhen-Tang Jing, Wei Liu, Shu-Xiang Wu, Yun He, Yan-Ting Lin, Wan-Nan Chen, Xin-Jian Lin, Xu Lin
Published Erratum

Correction: Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation

Zhen-Tang Jing et al. J Immunol. .
No abstract available

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Figures

FIGURE 6.
FIGURE 6.
Expression of HBsAg in mice renders them susceptible to ALF, and this effect is attenuated by administration of SC79. (A) SC79 treatment led to AKT hyperactivation in the livers of mice expressing wild-type and variant HBsAg by the AAV8 system. Protein extracts collected from the liver of untreated and SC79-treated mice were resolved on SDS-PAGE and immunoblotted with indicated Abs. SC79 was applied via i.p. injection at a concentration of 10 mg/kg body weight. (B) The protective effects of SC79 on an acute and lethal apoptotic hepatic injury induced by an anti-Fas agonist, Jo2 Ab. SC79-pretreated mice markedly extended the survival time from 6 to 13 h for AAV8-S204R, 6 to 14 h for AAV8-G145R, 9 to 15 h for AAV8-HBsAg, and 12 to 15 h for AAV8-control (all p < 0.01, n = 10 for all groups). (C) Macroscopic appearance of representative liver samples with H&E staining, and TUNEL staining 6 h after Jo2 treatment of the different groups as indicated. The histogram summarizes the average percentage of apoptotic cells in the livers of the indicated groups at various time points after Jo2 treatment. Original magnification ×200. (D) Caspase-8, -9, and -3/7 activity assay and (E) serum ALT and AST analyses, showing that significantly less severity with regard to apoptosis, caspase activities, and serum aminotransferase levels was observed in SC79-pretreated mice. Values are mean ± SD. n = 3. #p < 0.05, *p < 0.05.
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