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Review
. 2020 Sep;27(5):269-277.
doi: 10.1097/PAP.0000000000000270.

A 2020 Vision Into Hodgkin Lymphoma Biology

Stephanie N Hurwitz  1 , Adam Bagg
Affiliations
Review

A 2020 Vision Into Hodgkin Lymphoma Biology

Stephanie N Hurwitz et al. Adv Anat Pathol. 2020 Sep.

Abstract

Hodgkin lymphomas (HLs) are lymphoid neoplasms uniquely characterized by a paucity of neoplastic cells embedded in a supportive heterogenous cellular microenvironment. Although first described in the 19th century, systematic biological understanding of HLs has been hindered due to the challenges presented in studying the complex tumor microenvironment and scarce tumorigenic cells. Recent advances in single-cell isolation and characterization, sensitive mutational analytic tools, and multiplex immunohistochemical strategies have allowed further advances in understanding the development and progression of HL. Here we provide a current update on the chromosomal and mutational abnormalities seen in HL, the impact of Epstein-Barr virus infection on driving a subset of HLs, and the possibility of disease monitoring via high-sensitivity detection of genetic aberrations. We also discuss recent developments in understanding the intricate microenvironment through intercellular cross-talk, and describe novel potential biomarkers to aid in distinction of HL from other overlapping entities.

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References

    1. Küppers R. The biology of Hodgkin’s lymphoma. Nat Rev Cancer. 2009;9:15–27.
    1. Reed DM. On the pathological changes in Hodgkin’s disease, with especial reference to its relation to tuberculosis. Johns Hopkins Hosp Rep. 1902;10:133–196.
    1. Houldsworth J, Chaganti RS. Comparative genomic hybridization: an overview. Am J Pathol. 1994;145:1253–1260.
    1. Ohshima K, Ishiguro M, Ohgami A, et al. Genetic analysis of sorted Hodgkin and Reed-Sternberg cells using comparative genomic hybridization. Int J Cancer. 1999;82:250–255.
    1. Chui DT, Hammond D, Baird M, et al. Classical Hodgkin lymphoma is associated with frequent gains of 17q. Genes Chromosomes Cancer. 2003;38:126–136.

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