Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jul;21(7):355-356.
doi: 10.1038/s41580-020-0258-4.

COVID-19: organoids go viral

Hans Clevers  1
Affiliations
Comment

COVID-19: organoids go viral

Hans Clevers. Nat Rev Mol Cell Biol. 2020 Jul.

Abstract

The coronavirus disease-19 (COVID-19) pandemic underscores the threat posed by newly emerging viruses. Understanding the biology of novel viruses rests in large part on in vitro models that allow viral replication. Human and animal organoids are now proving their value as an experimental virology platform.

PubMed Disclaimer

Conflict of interest statement

The author is inventor on several patents related to organoid technology.

Comment on

  • Replication of human noroviruses in stem cell-derived human enteroids.
    Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Ettayebi K, et al. Science. 2016 Sep 23;353(6306):1387-1393. doi: 10.1126/science.aaf5211. Epub 2016 Aug 25. Science. 2016. PMID: 27562956 Free PMC article.

References

    1. Berry M, Gamieldien J, Fielding B. Identification of new respiratory viruses in the new millennium. Viruses. 2015;7:996–1019. doi: 10.3390/v7030996. - DOI - PMC - PubMed
    1. Lancaster MA, Knoblich JA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science. 2014;345:1247125. doi: 10.1126/science.1247125. - DOI - PubMed
    1. Ettayebi K, et al. Replication of human noroviruses in stem cell–derived human enteroids. Science. 2016;353:1387. doi: 10.1126/science.aaf5211. - DOI - PMC - PubMed
    1. Platt DJ, Miner JJ. Consequences of congenital Zika virus infection. Curr. Opin. Virol. 2017;27:1–7. doi: 10.1016/j.coviro.2017.09.005. - DOI - PMC - PubMed
    1. Hui KPY, et al. Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures. Lancet Respir. Med. 2018;6:846–854. doi: 10.1016/S2213-2600(18)30236-4. - DOI - PubMed