Blocking SIRPα could restore macrophage appetite and mitigate pneumonia

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Comment

Yvonne Bordon. Nat Rev Immunol. 2020 Jun.

. 2020 Jun;20(6):349.

doi: 10.1038/s41577-020-0339-9.

No abstract available

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Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis.
Roquilly A, Jacqueline C, Davieau M, Mollé A, Sadek A, Fourgeux C, Rooze P, Broquet A, Misme-Aucouturier B, Chaumette T, Vourc'h M, Cinotti R, Marec N, Gauttier V, McWilliam HEG, Altare F, Poschmann J, Villadangos JA, Asehnoune K. Roquilly A, et al. Nat Immunol. 2020 Jun;21(6):636-648. doi: 10.1038/s41590-020-0673-x. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424365

1. Roquilly, A. et al. SIRPα triggers tolerogenic training of resident alveolar macrophages after inflammation, leading to immune paralysis and increased susceptibility to secondary pneumonia. Nat. Immunol. https://doi.org/10.1038/s41590-020-0673-x (2020)