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Comment
. 2020 Sep 1;112(9):968-969.
doi: 10.1093/jnci/djaa074.

RE: Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study

Burkhard H Brandt  1 , Natalia Bednarz-Knoll  2 , Johannes Kleinheinz  3 , Andre Franke  4 , Thomas Fillies  5
Affiliations
Comment

RE: Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study

Burkhard H Brandt et al. J Natl Cancer Inst. .
No abstract available

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Figures

Figure 1.
Figure 1.
Epidermal growth factor receptor (EGFR) genotypes in normal population, oral premalignancy, and oral cancer. Frequency of EGFR CA SSR I allele length dichotomized for 18 or less and for greater than 18 CA repeats in a healthy German reference cohort (N%, n = 1333), CMS Muenster leukoplakia without cancer (OPL%, n = 391), CMS Muenster leukoplakia with cancer (CaOPL%, n = 12), and CMS Muenster leukoplakia with tongue cancer (CaTongueOPL%, n = 7).
See this image and copyright information in PMC

Comment in

  • Response to Brandt, Bednarz-Knoll, Kleinheinz et al.
    Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, Lingen MW, Silverberg MJ. Chaturvedi AK, et al. J Natl Cancer Inst. 2020 Sep 1;112(9):970-971. doi: 10.1093/jnci/djaa075. J Natl Cancer Inst. 2020. PMID: 32483585 Free PMC article. No abstract available.

Comment on

References

    1. Chaturvedi AK, Udaltsova N, Engels EA, et al.Oral leukoplakia and risk of progression to oral cancer: a population-based cohort study. J Natl Cancer Inst. 2020;112(10):djz238.10.1093/jnci/djz238 - DOI - PMC - PubMed
    1. Grandis JR, Melhem MF, Barnes EL, Tweardy DJ, Elevated levels of transforming growth factor a and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer . Cancer Res. 1996;78(6):1284–3584. - PubMed
    1. Werkmeister R, Brandt B, Joos U.. Aberrations of erbB-1 and erbB-2 oncogenes in non-dysplastic leukoplakias of the oral cavity. Br J Oral Maxillofac Surg. 1999;37(6):477–480. - PubMed
    1. William WN Jr, Papadimitrakopoulou V, Lee JJ, et al.Erlotinib and the risk of oral cancer: The Erlotinib Prevention of Oral Cancer (EPOC) randomized clinical trial. JAMA Oncol. 2016;2(2):209–216. - PMC - PubMed
    1. Brandt B, Meyer-Staeckling S, Schmidt H, Agelopoulos K, Buerger H, Mechanisms of EGFR gene transcription modulation: relationship to cancer risk and therapy response. Clin Cancer Res. 2006;12(24):7252–7260. - PubMed