Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;49(4):289-92.
doi: 10.1159/000132680.

Mapping studies and expression of genes located on human chromosome 11, band q23

P D Savage  1 , C Jones, J Silver, A H Geurts van Kessel, R Gonzalez-Sarmiento, L Palm, C A Hanson, J H Kersey
Affiliations

Mapping studies and expression of genes located on human chromosome 11, band q23

P D Savage et al. Cytogenet Cell Genet. 1988.

Abstract

Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen--NCAM--CD3([G, D], E)--parallel--(ETS1, THY1)--11qter.

PubMed Disclaimer

Publication types

Substances