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. 2020 Oct;42(10):2791-2800.
doi: 10.1002/hed.26308. Epub 2020 Jun 2.

Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma

Karine A Al Feghali  1 , Bassem Y Youssef  2 , Abdallah S R Mohamed  1   3 , Lara Hilal  2 , Blaine D Smith  1 , Ibrahim Abu-Gheida  1 , Georges Farha  4 , G Brandon Gunn  1 , Jack Phan  1 , Jan Lewin  5 , Apurva Thekdi  6 , William H Morrison  1 , Adam S Garden  1 , Clifton David Fuller  1 , David I Rosenthal  1
Affiliations

Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma

Karine A Al Feghali et al. Head Neck. 2020 Oct.

Abstract

Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT).

Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed.

Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P = .76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P = .1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P = .83). On multivariate analysis, younger age was the only independent predictor of improved OS (P = .0002).

Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.

Keywords: T2; larynx; outcomes; radiotherapy; survival.

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Conflict of interest statement

COI Disclosure: Authors declare no COI.

Figures

Fig. 1.
Fig. 1.
Kaplan Meier curves for freedom from distant metastasis (FDM), local control (LC), locoregional control (LRC), and ultimate locoregional control (uLRC).
Fig. 2.
Fig. 2.
Kaplan Meier curves showing (A) local control (LC), (B) utimate locoregional control (uLRC), (C) disease-specific survival (DSS), and (D) overall survival (OS) by RT technique (IMRT vs. non-IMRT) through 96 months.
Fig. 2.
Fig. 2.
Kaplan Meier curves showing (A) local control (LC), (B) utimate locoregional control (uLRC), (C) disease-specific survival (DSS), and (D) overall survival (OS) by RT technique (IMRT vs. non-IMRT) through 96 months.
Fig. 2.
Fig. 2.
Kaplan Meier curves showing (A) local control (LC), (B) utimate locoregional control (uLRC), (C) disease-specific survival (DSS), and (D) overall survival (OS) by RT technique (IMRT vs. non-IMRT) through 96 months.
Fig. 2.
Fig. 2.
Kaplan Meier curves showing (A) local control (LC), (B) utimate locoregional control (uLRC), (C) disease-specific survival (DSS), and (D) overall survival (OS) by RT technique (IMRT vs. non-IMRT) through 96 months.
See this image and copyright information in PMC

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