Effect of anti-thymocyte serum, anti-macrophage serum, and latex particles on the therapeutic efficacy of BCG or Corynebacterium liquefaciens (Propionibacterium acnes C7) in syngeneic mice

Abstract

In a syngeneic mouse-tumor system, anti-thymocyte serum, anti-macrophage serum, and latex particles were used for a comparative study of the immunotherapeutic efficacy of intradermal inoculation of tumor cell-BCG and tumor cell-Corynebacterium liquefaciens (=Propionibacterium acnes C7) vaccines. Anti-thymocyte serum treatment nullified suppression of tumor mediated by BCG (living and nonliving) and living C. liquefaciens. However, the effect of nonliving C. liquefaciens was not affected so much by treatment with anti-thymocyte serum. Treatment with anti-macrophage serum or latex particles also imparied the therapeutic efficacy of living BCG, but had no influence on the efficacy of living and nonliving C. liquefaciens.