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Review
. 2020 May 30;7(6):31.
doi: 10.3390/medicines7060031.

Genista tridentata L.: A Rich Source of Flavonoids with Anti-inflammatory Activity

Diana C G A Pinto  1 , Mark A M Simões  1 , Artur M S Silva  1
Affiliations
Review

Genista tridentata L.: A Rich Source of Flavonoids with Anti-inflammatory Activity

Diana C G A Pinto et al. Medicines (Basel). .

Abstract

: Background: Genista tridentata L. is an endemic species from the Iberian Peninsula used in Portuguese traditional medicine to treat inflammation-related diseases; this and other health-promoting effects are usually associated with the flavonoids produced by this species. In fact, anti-inflammatory properties were established for several of these flavonoid derivatives. Methods: A careful survey of the reported data, using mainly the Scopus database and Genista tridentata and Pterospartum tridentatum as keywords, was done. We have examined the papers involving the plant and those about the most relevant flavonoids anti-inflammatory activity. Results: The literature survey demonstrates that species are used to treat several health problems such as antihyperglycemia, hypertension, and inflammatory episodes. It was also possible to establish its richness in flavonoid derivatives, from which several are potential anti-inflammatory agents. Conclusions: From our described and discussed analysis, it can be concluded that Genista tridentata is an excellent source of bioactive flavonoids. Moreover, its traditional use to treat inflammation episodes may be due to its flavonoid content, from which genistein, biochanin A, rutin, and daidzein can be emphasized.

Keywords: Genista tridentata; Pterospartum tridentatum; anti-inflammatory; biochanin A; daidzein; flavonols; genistein; isoflavones; rutin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of the classes of flavonoid derivatives found in G. tridentata.
Figure 2
Figure 2
Structure of some flavonoid derivatives found in G. tridentata.
Figure 3
Figure 3
Biochanin A 1h and prunetin 1d structures.
Figure 4
Figure 4
Daidzein 1j structure.
Figure 5
Figure 5
Genistein 1e structure.
Figure 6
Figure 6
Rutin 3c structure.
See this image and copyright information in PMC

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