Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb;48(1):455-470.
doi: 10.1007/s00068-020-01408-y. Epub 2020 Jun 2.

β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury

Mengyang Yu #  1 , Qi Lv #  2   3 , Jie Shi  2   3 , Yahua Liu  1 , Haojun Fan  2   3 , Hui Ding  2   3 , Ziquan Liu  2   3 , Juan Cao  4 , Yanhua Gong  2   3 , Shike Hou  5   6
Affiliations

β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury

Mengyang Yu et al. Eur J Trauma Emerg Surg. 2022 Feb.

Abstract

Background: Crush injury/crush syndrome (CI/CS) is the second most common cause of death during earthquakes. Most studies of CI/CS have mainly focused on kidney injury after decompression. Few studies have focused on myocardial injury caused by crush injury and its potential mechanisms.

Methods: We first verified cardiomyocyte injury during compression in rats with a crush injury. The survival rate, electrocardiographic results, histological results, catecholamine changes and cardiac β1-AR expression were evaluated. Next, we explored the effects of pretreatment with a selective β1-blocker (bisoprolol) with or without fluid resuscitation on rats with a crush injury. In addition to evaluating the survival rates, biochemical and histological analyses and echocardiographic measurements were also performed.

Results: Reduced heart rates, elevated ST segments, and tall-peaked T waves were observed in the rats with a crush injury. The changes in the myocardial enzymes and pathological results demonstrated that myocardial damage occurred during compression in rats with a crush injury. The levels of the catecholamine norepinephrine in both the serum and myocardial tissue were elevated during compression. Pretreatment with a selective β1-blocker combined with fluid resuscitation significantly improved the survival rates of the rats with lethal crush injury. The myocardial enzymes and pathological results showed that the combined therapy decreased myocardial damage. The echocardiography measurements showed that the rats that received the combined therapy exhibited decreased left ventricular mass (LVM), left ventricular volume at end-systole (LVVs) and left ventricular internal diameter (LVID) compared with the rats with a crush injury.

Conclusions: Our findings demonstrated the presence of myocardial injury in the early stage of compression in rats with a crush injury. Pretreatment with a β1-blocker (bisoprolol) with fluid resuscitation significantly reduced mortality, decreased myocardial tissue damage, and improved ventricular remodelling in rats with a lethal crush injury.

Keywords: Beta-adrenergic receptors; Crush injury; Myocardial injury; Ventricular remodelling; β-Blocker.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Speck K, Schneider BS, Deashinta N. A rodent model to advance the field treatment of crush muscle injury during earthquakes and other natural disasters. Biol Res Nurs. 2013;15(1):17–25. https://doi.org/10.1177/1099800411414698 . - DOI - PubMed - PMC
    1. Sever MS, Vanholder R. Crush syndrome: a case report and review of the literature. J Emerg Med. 2015;48(6):730–1. https://doi.org/10.1016/j.jemermed.2014.07.063 . - DOI - PubMed - PMC
    1. Sever MS, Vanholder R. Management of crush syndrome casualties after disasters. Rambam Maimonides Med J. 2011;2(2):e0039. https://doi.org/10.5041/RMMJ.10039 . - DOI - PubMed - PMC
    1. Zhang BF, Wang PF, Cong YX, Lei JL, Wang H, Huang H, et al. Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-alpha and c-Jun N-terminal kinase pathway. J Orthop Surg Res. 2017;12(1):110. https://doi.org/10.1186/s13018-017-0614-z . - DOI - PubMed - PMC
    1. Chavez LO, Leon M, Einav S, Varon J. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Crit Care. 2016;20(1):135. https://doi.org/10.1186/s13054-016-1314-5 . - DOI - PubMed - PMC

LinkOut - more resources