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Review
. 2020 Dec;38(6):1888-1898.
doi: 10.1007/s10637-020-00955-w. Epub 2020 Jun 2.

The old CEACAMs find their new role in tumor immunotherapy

Zi-Wen Han #  1   2 , Zhi-Wu Lyv #  3 , Bin Cui #  3 , Ying-Ying Wang  1   2 , Jun-Ting Cheng  1   2 , Ying Zhang  1   2 , Wen-Qi Cai  1   2 , Yang Zhou  1   2 , Zhao-Wu Ma  1   2 , Xian-Wang Wang  1   2   4 , Xiao-Chun Peng  1   2   5 , Shu-Zhong Cui  6 , Ying Xiang  7   8 , Mo Yang  9 , Hong-Wu Xin  10   11
Affiliations
Review

The old CEACAMs find their new role in tumor immunotherapy

Zi-Wen Han et al. Invest New Drugs. 2020 Dec.

Erratum in

Abstract

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) contain 12 family members(CEACAM1、CEACAM3、CEACAM4、CEACAM5、CEACAM6、CEACAM7、CEACAM8、CEACAM16、CEACAM18、CEACAM19、CEACAM20 and CEACAM21)and are expressed diversely in different normal and tumor tissues. CEA (CEACAM5) has been used as a tumor biomarker since 1965. Here we review the latest research and development of the structures, expression, and function of CEACAMs in normal and tumor tissues, and their application in the tumor diagnosis, prognosis, and treatment. We focus on recent clinical studies of CEA targeted cancer immunotherapies, including bispecific antibody (BsAb) for radio-immuno-therapy and imaging, bispecific T cell engager (BiTE) and chimeric antigen receptor T cells (CAR-T). We summarize the promising clinical relevance and challenges of these approaches and give perspective view for future research. This review has important implications in understanding the diversified biology of CEACAMs in normal and tumor tissues, and their new role in tumor immunotherapy.

Keywords: Bispecific Antibody (BsAb); Bispecific T cell engager (BiTE); Carcinoembryonic Antigen-related Cell Adhesion Molecules (CEACAMs); Chimeric Antigen Receptor T cell (CAR-T); Tumor immunotherapy.

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