BCL9/BCL9L in hepatocellular carcinoma: will it or Wnt it be the next therapeutic target?

Akshata Moghe^{1

2}, Satdarshan P Monga^{3

4

5}

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² Pittsburgh Liver Research Center, School of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 200 Lothrop Street S-422 BST, Pittsburgh, PA, 15261, USA.
³ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.
⁴ Pittsburgh Liver Research Center, School of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 200 Lothrop Street S-422 BST, Pittsburgh, PA, 15261, USA. smonga@pitt.edu.
⁵ Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.

Editorial

Akshata Moghe et al. Hepatol Int. 2020 Jul.

. 2020 Jul;14(4):460-462.

doi: 10.1007/s12072-020-10059-5. Epub 2020 Jun 1.

Akshata Moghe^{1

2}, Satdarshan P Monga^{3

4

5}

¹ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² Pittsburgh Liver Research Center, School of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 200 Lothrop Street S-422 BST, Pittsburgh, PA, 15261, USA.
³ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.
⁴ Pittsburgh Liver Research Center, School of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, 200 Lothrop Street S-422 BST, Pittsburgh, PA, 15261, USA. smonga@pitt.edu.
⁵ Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.

No abstract available

References

1. Yarchoan M, et al., Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res, 2019. 79(17): p. 4326–4330. - PMC - PubMed
1. Russell JO and Monga SP, Wnt/beta-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology. Annu Rev Pathol, 2018. 13: p. 351–378. - PMC - PubMed
1. Cancer Genome Atlas Research Network. Electronic address, w.b.e. and N. Cancer Genome Atlas Research, Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell, 2017. 169(7): p. 1327–1341 e23. - PMC - PubMed
1. Laurent-Puig P and Zucman-Rossi J, Genetics of hepatocellular tumors. Oncogene, 2006. 25(27): p. 3778–86. - PubMed
1. Schulze K, et al., Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet, 2015. 47(5): p. 505–511. - PMC - PubMed