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. 2020 Oct;70(10):1639-1648.
doi: 10.1007/s12031-020-01544-5. Epub 2020 Jun 1.

Selegiline (L-Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alternative Therapy in Transient Global Ischemia

Mahroo Ahmari  1   2 , Ali Sharafi  1   3 , Javad Mahmoudi  4 , Iraj Jafari-Anarkoli  5 , Mahmoud Gharbavi  3 , Mir-Jamal Hosseini  6   7
Affiliations

Selegiline (L-Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alternative Therapy in Transient Global Ischemia

Mahroo Ahmari et al. J Mol Neurosci. 2020 Oct.

Abstract

Selegiline (L-deprenyl) is the major drug which is used in the treatment of Parkinson's disease because of its neurotrophic and antiapoptotic properties. Previous studies suggested that low dose of L-methamphetamine (L-METH) caused lower mortality rate in patients with severe traumatic brain injury. As L-methamphetamine is one of the metabolites of selegiline, the present study aims to examine whether L-deprenyl can improve cognitive, biochemical, and histopathological injury in animal model of transient global ischemia. The animals were randomized in ten groups orally gavaged three times a week for 28 days. Then, novel object recognition (NOR) was conducted to assess their behavioral abnormality. After scarification of the rats, their brains were divided into two sections to measure oxidative stress parameters and perform pathological evaluations in rats. Our data revealed the involvement of oxidative stress, behavioral despair, and pathological data in transient global ischemia rats. Significant recovery in cognitive behavior, oxidative stress biomarker, and number of dead cell in histopathological assay was observed in rats treated with 1,2 and 4 mg/kg of selegiline. So, selegiline appears to be useful in alternative therapy of transient global ischemia.

Keywords: Behavioral abnormality; Oxidative stress; Selegiline; Transient global ischemia.

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References

    1. Amiri S et al (2017) Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice. Neuroscience 340:373–383 - DOI
    1. Antunes M, Biala G (2012) The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process 13:93–110 - DOI
    1. Arteaga O, Revuelta M, Urigüen L, Alvarez A, Montalvo H, Hilario E (2015) Pretreatment with resveratrol prevents neuronal injury and cognitive deficits induced by perinatal hypoxia-ischemia in rats. PLoS One 10(11):e0142424
    1. Bartolo M, Zucchella C, Capone A, Sandrini G, Pierelli F (2015) An explorative study regarding the effect of l-deprenyl on cognitive and functional recovery in patients after stroke. J Neurol Sci 349:117–123 - DOI
    1. Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 239:70–76 - DOI

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