Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr;37(2):214-220.
doi: 10.5114/ada.2018.79567. Epub 2018 Nov 14.

Evaluation of carotid intima media thickness and hematologic inflammatory markers in patients with chronic spontaneous urticaria

Mahizer Yaldiz  1 , Kiyasettin Asil  2
Affiliations

Evaluation of carotid intima media thickness and hematologic inflammatory markers in patients with chronic spontaneous urticaria

Mahizer Yaldiz et al. Postepy Dermatol Alergol. 2020 Apr.

Abstract

Introduction: Low grade inflammation is associated with chronic spontaneous urticaria (CSU) and atherosclerosis. There are little data on the relationship between urticarial inflammation and atherosclerosis. The neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) have recently been studied in many diseases as a biomarker of inflammation.

Aim: To evaluate hematologic inflammatory parameters and subclinical atherosclerosis in CSU patients.

Material and methods: C-reactive protein (CRP), NLR, PLR, MPV and carotid intima media thickness (CIMT) in CSU patients were compared with healthy controls. Thirty CSU patients and 30 healthy controls participated in the study.

Results: Thirty CSU patients and 30 healthy controls participated in the study. 53.3% of the patient group were females, 46.7% were males and the mean age was 37.7 ±7.7. 53.3% of the healthy control group were females, 46.7% were males and the mean age was 37.1 ±7.2. Body mass index was 24.63 ±2.7 kg/m2 in the patient group and 24.83 ±2.5 kg/m2 in the control group. Left and right CIMT and CRP values were higher in CSU patients and high-density lipoproteins (HDL) values were lower in the CSU patients. There was a positive correlation between the right and left CIMT and urticaria activity severity 4 (UAS4), disease severity, and triglycerides in the patient group, also a negative correlation was found between the right and left CIMT and the HDL values. C-reactive protein was also correlated with UAS4 and disease severity.

Conclusions: This is the first study to evaluate subclinical atherosclerosis in CSU patients. Chronic spontaneous urticaria may be associated with an increased atherosclerotic risk. Serum CRP concentration can also be used as an objective parameter to evaluate disease severity.

Keywords: carotid intima media thickness; chronic spontaneous urticaria; hematologic inflammatory markers.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Kasperska-Zajac A. Acute-phase response in chronic urticaria. J Eur Acad Dermatol Venereol. 2012;26:665–72. - PubMed
    1. Zuberbier T, Aberer W, Asero R, et al. European Academy of Allergy and Clinical Immunology; Global Allergy and Asthma EuropeanNetwork; European DermatologyForum; World Allergy Organization The EAACI/GA(2)LEN/EDF/WAO guideline: for the definition, classification, diagnosis and management of urticaria: the 2013 revision and update. Allergy. 2014;69:868–87. - PubMed
    1. Imtiaz F, Shafique K, Mirza SS, et al. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5:2. - PMC - PubMed
    1. Conti P, Shaik-Dasthagırısaeb Y. Atherosclerosis: a chronic inflammatory disease mediated by mast cell. Cent Eur J Immunol. 2015;40:380–6. - PMC - PubMed
    1. Kressel G, Trunz B, Bub A, et al. Systemic and vascular markers of inflammation in relation to metabolic syndrome and insulin resistance in adults with elevated atherosclerosis risk. Atherosclerosis. 2009;202:263–71. - PubMed