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. 2020 Apr 18;21(3):84-86.
doi: 10.1002/jgf2.308. eCollection 2020 May.

Reversible lesion in the splenium of the corpus callosum in a patient with chronic alcoholism

Syuichi Tetsuka  1 , Takeshi Kamimura  2 , Gaku Ohki  2 , Ritsuo Hashimoto  1
Affiliations

Reversible lesion in the splenium of the corpus callosum in a patient with chronic alcoholism

Syuichi Tetsuka et al. J Gen Fam Med. .

Abstract

Marchiafava-Bignami disease (MBD) is often diagnosed in chronic alcoholics. The disease processes typically involve the corpus callosum and clinically presents with various manifestations on the basis of clinical condition, extent of the splenium of the corpus callosum involvement at brain magnetic resonance imaging (MRI), and prognosis. We report a patient affected by MBD, who presented an isolated reversible splenial lesion at brain MRI and achieved a favorable recovery.

Keywords: Marchiafava‐Bignami disease; chronic alcoholics; reversible lesion; splenium of the corpus callosum.

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Conflict of interest statement

The authors have stated explicitly that there are no conflict of interest in connection with this article.

Figures

Figure 1
Figure 1
(A and B); MRI studies at onset. Diffusion‐weighted images (DWI) show hyperintensity involving the splenium of the corpus callosum (arrowhead) (A) with corresponding hypointensity on apparent diffusion coefficient (ADC) images (B). (C and D); MRI studies at two‐week follow‐up. DWI shows normal signal in the splenium of the corpus callosum (C). There is no abnormal lesion on fluid‐attenuated inversion recovery (FLAIR) (D)
See this image and copyright information in PMC

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