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Case Reports
. 2020 Apr 24;6(6):521-523.
doi: 10.1016/j.jdcr.2020.03.011. eCollection 2020 Jun.

Multiple subcutaneous juvenile xanthogranulomas with a blue hue in a neonate: An atypical presentation

Michael P Ryan  1 , Adam V Nguyen  2 , Matthew J Hay  3 , Brent C Kelly  2 , Sharon S Raimer  2
Affiliations
Case Reports

Multiple subcutaneous juvenile xanthogranulomas with a blue hue in a neonate: An atypical presentation

Michael P Ryan et al. JAAD Case Rep. .
No abstract available

Keywords: JMML, juvenile myelomonocytic leukemia; JXG, juvenile xanthogranuloma; NF1, neurofibromatosis type 1; atypical; blue; infant; juvenile; neonate; nodule; pediatric; subcutaneous; unusual; xanthogranuloma.

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Figures

Fig 1
Fig 1
White arrows point to blue-gray patches and nodules on the abdomen, leg, and back present at birth representing JXG.
Fig 2
Fig 2
At 5 weeks of age, white arrows point to subcutaneous nodules with overlying blue hue on the leg.
Fig 3
Fig 3
A, Low-power view of punch biopsy shows dermal proliferation of histiocytes. B, High-power view shows mononuclear and touton giant cells admixed with lymphocytes and occasional eosinophils. (A and B, Hematoxylin-eosin stain; original magnifications: A, ×20; B, ×400.)
Fig 4
Fig 4
By 4 months of age, the subcutaneous nodules have become orange to tan in color as seen on the leg, back, and abdomen.
See this image and copyright information in PMC

References

    1. Gianotti F., Caputo R. Histiocytic syndromes: a review. J Am Acad Dermatol. 1985;13(3):383–404. - PubMed
    1. Hernandez-Martin A., Baselga E., Drolet B.A., Esterly N.B. Juvenile xanthogranuloma. J Am Acad Dermatol. 1997;36(3):355–367. - PubMed
    1. Janssen D., Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry. Am J Surg Pathol. 2005;29(1):21–28. - PubMed
    1. Freyer D.R., Kennedy R., Bostrom B.C., Kohut G., Dehner L.P. Juvenile xanthogranuloma: forms of systemic disease and their clinical implications. J Pediatr. 1996;129(2):227–237. - PubMed
    1. Zvulunov A., Barak Y., Metzker A. Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia: world statistical analysis. Arch Derm. 1995;131(8):904–908. - PubMed

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