Mid-Ventricular Takotsubo Cardiomyopathy
- PMID: 32491438
- Bookshelf ID: NBK557506
Mid-Ventricular Takotsubo Cardiomyopathy
Excerpt
Takotsubo Cardiomyopathy is a reversible myocardial injury that presents with distinctive regional wall abnormalities of the left ventricle — first identified and discussed in the early 1990s in Japan. This condition, predominantly found in postmenopausal females, usually presents after significant emotional or physical stressors. On presentation, patients have signs and symptoms of typical acute coronary artery syndrome (cardiac enzyme elevation, ischemic electrocardiogram changes, and chest pain) but lack coronary obstruction on angiographic evaluation. Different forms of this cardiomyopathy over time are seen in patients and are widely categorized into two categories.
Typical Variant
This type of Takotsubo involves the apical ballooning of the left ventricle during systole with likely hyperkinesis of the basal segments. The majority of patients with Takotsubo cardiomyopathy syndrome fall into the typical variant category.
Atypical Variants
This type of Takotsubo involves the basal, focal, mid-ventricular, biventricular (apical and right ventricle), isolated right ventricular, and global variants.
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-
- Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. Eur Heart J. 2018 Jun 07;39(22):2032-2046. - PMC - PubMed
-
- Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J. 2006 Jul;27(13):1523-9. - PubMed
-
- Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N Engl J Med. 2015 Sep 03;373(10):929-38. - PubMed
-
- Nef HM, Möllmann H, Kostin S, Troidl C, Voss S, Weber M, Dill T, Rolf A, Brandt R, Hamm CW, Elsässer A. Tako-Tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J. 2007 Oct;28(20):2456-64. - PubMed
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