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Book

Pulmonary Regurgitation

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Pulmonary Regurgitation

Pradyumna Agasthi et al.
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Excerpt

The pulmonary valve is a vital component of the cardiovascular system, serving as a thin tricuspid structure. This valve prevents backward flow into the right ventricle after propelling blood into the low-pressure pulmonary circulation. Pulmonary regurgitation occurs when blood flows from the pulmonary artery back into the right ventricle during diastole. Physiologic pulmonary regurgitation, characterized as a trace, is commonly found in nearly all individuals, especially those advanced in age.

Specific pathological conditions may result in excessive and clinically significant regurgitation, negatively impacting proper ventricle function. This regurgitation can manifest as clinical symptoms of right-sided volume overload and heart failure. Pulmonary regurgitation is not typically the primary pathological process but rather a secondary finding associated with an underlying condition such as pulmonary hypertension or dilated cardiomyopathy. These underlying processes play a significant role in the development of pulmonary regurgitation.

Understanding the intricate workings of the pulmonary valve and the factors contributing to pulmonary regurgitation is crucial for comprehensive patient care. By elucidating the mechanisms involved in the pathogenesis of pulmonary regurgitation, healthcare professionals can enhance their ability to diagnose, manage, and treat patients with this condition, ultimately improving patient outcomes and quality of life.

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Conflict of interest statement

Disclosure: Pradyumna Agasthi declares no relevant financial relationships with ineligible companies.

Disclosure: Anu Saji declares no relevant financial relationships with ineligible companies.

Disclosure: Saurabh Sharma declares no relevant financial relationships with ineligible companies.

References

    1. Mongeon FP, Ben Ali W, Khairy P, Bouhout I, Therrien J, Wald RM, Dallaire F, Bernier PL, Poirier N, Dore A, Silversides C, Marelli A. Pulmonary Valve Replacement for Pulmonary Regurgitation in Adults With Tetralogy of Fallot: A Meta-analysis-A Report for the Writing Committee of the 2019 Update of the Canadian Cardiovascular Society Guidelines for the Management of Adults With Congenital Heart Disease. Can J Cardiol. 2019 Dec;35(12):1772-1783. - PubMed
    1. Baumgartner H, De Backer J. The ESC Clinical Practice Guidelines for the Management of Adult Congenital Heart Disease 2020. Eur Heart J. 2020 Nov 14;41(43):4153-4154. - PubMed
    1. Writing Committee Members. Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT, Rigolin VH, Sundt TM, Thompson A, Toly C, ACC/AHA Joint Committee Members. O'Gara PT, Beckman JA, Levine GN, Al-Khatib SM, Armbruster A, Birtcher KK, Ciggaroa J, Deswal A, Dixon DL, Fleisher LA, de las Fuentes L, Gentile F, Goldberger ZD, Gorenek B, Haynes N, Hernandez AF, Hlatky MA, Joglar JA, Jones WS, Marine JE, Mark D, Palaniappan L, Piano MR, Spatz ES, Tamis-Holland J, Wijeysundera DN, Woo YJ. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Thorac Cardiovasc Surg. 2021 Aug;162(2):e183-e353. - PubMed
    1. Renella P, Aboulhosn J, Lohan DG, Jonnala P, Finn JP, Satou GM, Williams RJ, Child JS. Two-dimensional and Doppler echocardiography reliably predict severe pulmonary regurgitation as quantified by cardiac magnetic resonance. J Am Soc Echocardiogr. 2010 Aug;23(8):880-6. - PubMed
    1. Murphy JG, Gersh BJ, Mair DD, Fuster V, McGoon MD, Ilstrup DM, McGoon DC, Kirklin JW, Danielson GK. Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med. 1993 Aug 26;329(9):593-9. - PubMed

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