Rufinamide
- PMID: 32491527
- Bookshelf ID: NBK557595
Rufinamide
Excerpt
Rufinamide is one of the anti-seizure drugs (ASD) used as an add-on therapy to treat seizures associated with Lennox Gastaut syndrome, and it is structurally unrelated to other traditional ASDs. This CME activity provides a brief and illustrative review of this drug's FDA-approved indications and pharmacodynamic and pharmacokinetic properties. This activity will also highlight the side effects, contraindications, and dosing regimens of this drug and will also discuss the practice parameters of the American Academy of Neurology guidelines regarding the utility of this drug in clinical practice.
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References
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- Perucca E, Cloyd J, Critchley D, Fuseau E. Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. Epilepsia. 2008 Jul;49(7):1123-41. - PubMed
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- Deeks ED, Scott LJ. Rufinamide. CNS Drugs. 2006;20(9):751-60; discussion 761. - PubMed
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- Asadi-Pooya AA. Lennox-Gastaut syndrome: a comprehensive review. Neurol Sci. 2018 Mar;39(3):403-414. - PubMed
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