Pimavanserin
- PMID: 32491644
- Bookshelf ID: NBK557712
Pimavanserin
Excerpt
Pimavanserin is a medication used to treat and manage the hallucinations and delusions associated with Parkinson disease psychosis. It is in the atypical antipsychotic class of drugs. This activity reviews the indication, action, and contraindications for pimavanserin as a valuable agent in managing Parkinson disease psychosis. This activity will highlight the mechanism of action, adverse event profile, dosing, monitoring, relevant interactions, and other key factors pertinent for healthcare team members in the care of patients with Parkinson disease psychosis.
Copyright © 2025, StatPearls Publishing LLC.
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References
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- Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, Dhall R, Ballard C. Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet. 2014 Feb 08;383(9916):533-40. - PubMed
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- Espay AJ, Guskey MT, Norton JC, Coate B, Vizcarra JA, Ballard C, Factor SA, Friedman JH, Lang AE, Larsen NJ, Andersson C, Fredericks D, Weintraub D. Pimavanserin for Parkinson's Disease psychosis: Effects stratified by baseline cognition and use of cognitive-enhancing medications. Mov Disord. 2018 Nov;33(11):1769-1776. - PMC - PubMed
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- Ballard C, Banister C, Khan Z, Cummings J, Demos G, Coate B, Youakim JM, Owen R, Stankovic S, ADP Investigators Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study. Lancet Neurol. 2018 Mar;17(3):213-222. - PubMed
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