Diffuse Large B-Cell Lymphoma
- PMID: 32491728
- Bookshelf ID: NBK557796
Diffuse Large B-Cell Lymphoma
Excerpt
Lymphoma is the malignancy of the lymphocytes in the lymphoid system, and they can arise from B lymphocytes or T lymphocytes or the natural killer (NK) cells during their different stages of maturation. It can be classified into Hodgkins and Non-Hodgkins lymphoma (NHL). NHL constitutes about 80% of all lymphomas. B- cells are known to have functional diversity and property to transform into multiple pathways. Due to its functional diversity, it represents a heterogeneous group of diseases varying clinically and pathologically. More than 30 subtypes of NHL have been identified, and the common ones are diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).
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Sections
- Continuing Education Activity
- Introduction
- Etiology
- Epidemiology
- Pathophysiology
- Histopathology
- History and Physical
- Evaluation
- Treatment / Management
- Differential Diagnosis
- Toxicity and Adverse Effect Management
- Staging
- Prognosis
- Complications
- Consultations
- Deterrence and Patient Education
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
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- Coupland SE. The challenge of the microenvironment in B-cell lymphomas. Histopathology. 2011 Jan;58(1):69-80. - PubMed
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- Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med. 2004 Mar 25;350(13):1328-37. - PubMed
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- Eriksson M, Hardell L, Carlberg M, Akerman M. Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis. Int J Cancer. 2008 Oct 01;123(7):1657-63. - PubMed
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