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Book

Thrombin

Michael J. Lopez  1 , Srikanth Yandrapalli  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Thrombin

Michael J. Lopez et al.
Free Books & Documents

Excerpt

Thrombin is a topical hemostatic agent used to control and minimize blood loss during surgical procedures, is utilized in conjunction or as an alternative to standard surgical techniques. The Federal Drug Administration has approved three thrombin-based products: recombinant thrombin, human thrombin, and bovine thrombin. This activity provides a highlight and discusses critical elements about this drug and how this information can be useful for the medical team involved in the peri- and post-operative care of the patient.

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Conflict of interest statement

Disclosure: Michael Lopez declares no relevant financial relationships with ineligible companies.

Disclosure: Srikanth Yandrapalli declares no relevant financial relationships with ineligible companies.

References

    1. Lundblad RL, Bradshaw RA, Gabriel D, Ortel TL, Lawson J, Mann KG. A review of the therapeutic uses of thrombin. Thromb Haemost. 2004 May;91(5):851-60. - PubMed
    1. Lew WK, Weaver FA. Clinical use of topical thrombin as a surgical hemostat. Biologics. 2008 Dec;2(4):593-9. - PMC - PubMed
    1. Cheng CM, Meyer-Massetti C, Kayser SR. A review of three stand-alone topical thrombins for surgical hemostasis. Clin Ther. 2009 Jan;31(1):32-41. - PubMed
    1. Bhandari M, Ofosu FA, Mackman N, Jackson C, Doria C, Humphries JE, Babu SC, Ortel TL, Hoffman Van Thiel D, Walenga JM, Wahi R, Teoh KH, Fareed J. Safety and efficacy of thrombin-JMI: a multidisciplinary expert group consensus. Clin Appl Thromb Hemost. 2011 Feb;17(1):39-45. - PubMed
    1. Mishra A, Rao A, Pimpalwar Y. Ultrasound Guided Percutaneous Injection of Thrombin: Effective Technique for Treatment of Iatrogenic Femoral Pseudoaneurysms. J Clin Diagn Res. 2017 Apr;11(4):TC04-TC06. - PMC - PubMed

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