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Review
. 2020 Oct;92(10):1864-1874.
doi: 10.1002/jmv.26123. Epub 2020 Jun 19.

SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences

Melika Lotfi  1   2 , Nima Rezaei  3   4   5
Affiliations
Review

SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences

Melika Lotfi et al. J Med Virol. 2020 Oct.

Abstract

Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused novel coronavirus disease (COVID-19) pandemic, is the worldwide challenge. The virus is highly contagious, and clinical consequences were very divers. It is estimated that if no effective action is taken, COVID-19 could plague 90% of the world's population and kill over 40 million people. So, it is essential to understand the virus pathogenicity and follow the preventive methods to control the high morbidity and mortality rates. Meanwhile our current knowledge of COVID-19 is still limited, despite hard efforts of scientists and clinicians during last few months. In this review article, we have collected the latest data about characteristics, pathogenesis, clinical manifestations, and diagnostic methods of SARS-CoV-2.

Keywords: 2019-nCoV; COVID-19; SARS-CoV-2; clinical manifestations; virulence.

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References

    1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727‐733. - PMC - PubMed
    1. Cui J, Li F, Shi Z‐L. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17(3):181‐192. - PMC - PubMed
    1. Hanaei S, Rezaei N. COVID‐19: developing from an outbreak to a pandemic [published online ahead of print May 13, 2020]. Arch Med Res. 2020. 10.1016/j.arcmed.2020.04.021 - DOI - PMC - PubMed
    1. Guo Y‐R, Cao Q‐D, Hong Z‐S, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID‐19) outbreak–an update on the status. Mil Med Res. 2020;7(1):1‐10. - PMC - PubMed
    1. Tyrrell D, Bynoe M. Cultivation of viruses from a high proportion of patients with colds. Lancet. 1966;1:76‐77. - PubMed

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