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Comment
. 2020 Jun 2;31(6):1045-1047.
doi: 10.1016/j.cmet.2020.05.005.

Pseudomonas Persists by Feeding off Itaconate

Marah C Runtsch  1 , Luke A J O'Neill  2
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Pseudomonas Persists by Feeding off Itaconate

Marah C Runtsch et al. Cell Metab. .
Free article

Abstract

Itaconate is an immunometabolite with anti-inflammatory and anti-microbial properties. Riquelme et al. (2020) demonstrate that pathogenic Pseudomonas aeruginosa drives itaconate production by macrophages, which it then uses as a carbon source for biofilm formation, allowing it to persist during infection and suppress inflammation.

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