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Comment
. 2020 Jun 2;31(6):1047-1049.
doi: 10.1016/j.cmet.2020.05.010.

Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission

Megan L Rasmussen  1 , Gabriella L Robertson  1 , Vivian Gama  2
Affiliations
Comment

Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission

Megan L Rasmussen et al. Cell Metab. .

Abstract

Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, identifying a new organelle contact involved in maintaining mitochondrial homeostasis.

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Figures

Figure 1.
Figure 1.. A Simplified Look at the Process of Mitochondrial Fission
(1) ER-mitochondria contacts (MERCs) are formed to mark future sites of fission. F-actin polymerization concurrently aids in pre-constriction of the mitochondria. (2) Drp1 is recruited to its receptor proteins on the outer mitochondrial membrane through post-translational modifications. Drp1 matures and oligomerizes to initiate further constriction. (3) PI(4)P-containing Golgi-derived vesicles accumulate at Drp1 foci. (4) Further constriction of the outer mitochondrial membrane is promoted by F-actin filaments and Drp1 GTP hydrolysis. (5) Dynamic activity of all components results in complete fission of the mitochondria, with Golgi-derived vesicles dissociating prior to Drp1.
See this image and copyright information in PMC

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