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. 1977;54(2):176-82.
doi: 10.1159/000231822.

Restoration by levamisole of histamine-inhibited E rosette formation of T lymphocytes of patients with allergies

W De Cock, J De Crée, H Verhaegen

Restoration by levamisole of histamine-inhibited E rosette formation of T lymphocytes of patients with allergies

W De Cock et al. Int Arch Allergy Appl Immunol. 1977.

Abstract

Histamine significantly inhibited the E rosette formation of T lymphocytes of patients with allergies in vitro, but had no effect on the E rosette formation of T lymphocytes of healthy subjects. This inhibitory effect was obtained by concentrations of 3.10(-4) down to 3.10(-7) M histamine and depended on the time of incubation. Levamisole an antianergic chemotherapeutic agent, could restore the histamine-inhibited E rosette formation. It is postulated that patients with allergies possess a subpopulation of T lymphocytes bearing histamine receptors and that the inhibitory effect of histamine on E rosette formation is medicated by intracellular cAMP.

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