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Case Reports
. 2020 Jan-Dec:8:2324709620931239.
doi: 10.1177/2324709620931239.

COVID-19 Presented With Deep Vein Thrombosis: An Unusual Presenting

Lotfollah Davoodi  1 , Hamed Jafarpour  2 , Morteza Taghavi  3 , Alireza Razavi  2
Affiliations
Case Reports

COVID-19 Presented With Deep Vein Thrombosis: An Unusual Presenting

Lotfollah Davoodi et al. J Investig Med High Impact Case Rep. 2020 Jan-Dec.

Abstract

On December 31, 2019, the World Health Organization was informed of a cluster of cases of pneumonia of unknown cause detected in Wuhan City, Hubei Province, China. The pneumonia was caused by a virus called SARS-Cov-2 (severe acute respiratory syndrome coronavirus 2), which was later named coronavirus infectious disease 2019 (COVID-19). The symptoms most commonly reported by patients affected by COVID-19 include fever, dry cough, and shortness of breath. In this report, we present a case of a 57-year-old woman who presented to the clinic's infectious department with swelling, pain, warmth, and redness in the left leg who was treated with therapeutic heparin. There were no typical and distinguished symptoms of COVID-19, and she had no risk factor for deep vein thrombosis. Then chest X-ray revealed bilateral patchy ground-glass opacity, and computed tomography angiography was performed to rule out pulmonary thromboembolism, which showed no evidence of thrombosis. Left lower limb venous color Doppler ultrasound revealed dilatation and thrombosis in the external iliac and left iliac veins up to the level of the bifurcation of the common iliac veins, as well as thrombosis to the superficial and small saphenous veins. Because of ground-glass opacity and lymphopenia, nasal swabs were used for sampling, and SARS-CoV-2 nucleic acid was detected by reverse transcription polymerase chain reaction (RT-PCR). This case aims to arouse the medical staff's awareness of deep vein thrombosis as a clinical symptom of COVID-19 even if the patient has no typical symptoms of COVID-19.

Keywords: COVID-19; bilateral patchy ground-glass opacity; deep vein thrombosis; pulmonary thromboembolism.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Chest computed tomography showed persistent multifocal ground-glass opacities with or without superimposed reticulation.
Figure 2.
Figure 2.
Clinical image of redness, and leg swelling due to deep vein thrombosis.
Figure 3.
Figure 3.
Abdominal color Doppler ultrasound image for deep vein thrombosis detection.
See this image and copyright information in PMC

References

    1. Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-815. doi:10.1016/S0140-6736(20)30360-3 - DOI - PMC - PubMed
    1. Shen K, Yang Y, Wang T, et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement [published online February 7, 2020]. World J Pediatr. doi:10.1007/s12519-020-00343-7 - DOI - PMC - PubMed
    1. World Health Organization. Coronavirus disease (COVID-19) pandemic. Accessed May 16, 2020 https://www.who.int/emergencies/diseases/novel-coronavirus-2019?gclid=EA...
    1. Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17:259-260. - PMC - PubMed
    1. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145-148. - PMC - PubMed

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