Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2020 Jun 3;20(1):79.
doi: 10.1186/s12902-020-00560-1.

Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study

Yingchao Chen  1 , Jing Cheng  1 , Yi Chen  1 , Ningjian Wang  1 , Fangzhen Xia  1 , Chi Chen  1 , Bing Han  2 , Yingli Lu  3
Affiliations
Observational Study

Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study

Yingchao Chen et al. BMC Endocr Disord. .

Abstract

Background: Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population.

Methods: We did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9220 subjects were analyzed. Serum 25(OH) D, SUA, fasting plasma glucose (FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status.

Results: We enrolled 9220 Chinese adults, including 3681 males (age 55.57 ± 13.23 years) and 5539 females (age 54.31 ± 12.83 years). The levels of SUA were 352.07 ± 79.25 nmol/L and 269.29 ± 64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH) D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH) D (P < 0.001).

Conclusions: SUA was positively associated with 25(OH) D in the eastern Chinese population. Higher levels of serum 25(OH) D may be a potential predictor of HUA.

Keywords: Hyperuricemia; Public health; Uric acid; Vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of this study. We totally collected 12,770 subjects. After excluding participants who had missing data or specific disease states, finally, 9220 subjects were included
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bikle DD. Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. 2011;347(1–2):80–89. doi: 10.1016/j.mce.2011.05.017. - DOI - PMC - PubMed
    1. Skowron K, Pawlicka I, Gil K. The role of vitamin D in the pathogenesis of ocular diseases. Folia Med Cracov. 2018;58(2):103–118. - PubMed
    1. Maesaka JK, Fishbane S. Regulation of renal urate excretion: a critical review. Am J Kidney Dis. 1998;32(6):917–933. doi: 10.1016/S0272-6386(98)70067-8. - DOI - PubMed
    1. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981;78(11):6858–6862. doi: 10.1073/pnas.78.11.6858. - DOI - PMC - PubMed
    1. Bobulescu IA, Moe OW, et al. Renal transport of uric acid: evolving concepts and uncertainties. Adv Chronic Kidney Dis. 2012;19(6):358–371. doi: 10.1053/j.ackd.2012.07.009. - DOI - PMC - PubMed

Publication types