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Comment
. 2020 Aug;30(8):635-636.
doi: 10.1038/s41422-020-0340-7.

Fibroblasts fuel intestinal tumorigenesis

Dingzhi Wang  1 , Raymond N DuBois  2
Affiliations
Comment

Fibroblasts fuel intestinal tumorigenesis

Dingzhi Wang et al. Cell Res. 2020 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1. The role of COX-2-expressing fibroblasts in expansion of SCA-1+ intestinal stem-like cells and intestinal adenoma formation.
COX-2 converts arachidonic acid into PGs, including PGE2 in intestinal fibroblasts. PGE2 induces expansion of SCA-1+ reserve intestinal stem-like cells via an EP4-Yap1 pathway. PGE2 also accelerates intestinal adenoma formation accompanied by SCA-1+ cell expansion via an EP4-Yap1 pathway.
See this image and copyright information in PMC

Comment on

  • Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.
    Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Roulis M, et al. Nature. 2020 Apr;580(7804):524-529. doi: 10.1038/s41586-020-2166-3. Epub 2020 Apr 1. Nature. 2020. PMID: 32322056 Free PMC article.

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