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. 2020 Jun;19(6):374.
doi: 10.1038/d41573-020-00029-9.

GPR84: an immune response dial?

Megan L Wojciechowicz, Avi Ma'ayan

GPR84: an immune response dial?

Megan L Wojciechowicz et al. Nat Rev Drug Discov. 2020 Jun.
No abstract available

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Figures

Fig. 1 ∣
Fig. 1 ∣. Chemical tools to target GPR84 and their downstream effects.
Examples of agonists that activate the GPR84 receptor include embelin, 6-n-octylaminouracil (6-OAU), diindolylmethane, 2-(hexylthio)pyrimidine-4,6-diol (ZQ-16), 6-hexylamino-2,4(1H,3H)-pyrimidinedione (PSB-1584), and medium-chain fatty acids (9–14 carbons). GPR84 activation using the selective biased agonist DL-175 has been shown to lead to phagocytosis and a pro-inflammatory response. PBI-4050, an antagonist of GPR84 as well as an agonist of GPR40, reduced liver, pulmonary and kidney fibrosis in mouse and rat models.
See this image and copyright information in PMC

References

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