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. 2020 May 26;6(2):00099-2020.
doi: 10.1183/23120541.00099-2020. eCollection 2020 Apr.

Doxycycline for exacerbations of chronic obstructive pulmonary disease in outpatients: who benefits?

Patricia van Velzen  1 , Gerben Ter Riet  2   3 , Paul Brinkman  1 , Peter J Sterk  1 , Jan M Prins  4
Affiliations

Doxycycline for exacerbations of chronic obstructive pulmonary disease in outpatients: who benefits?

Patricia van Velzen et al. ERJ Open Res. .

Abstract

No clinical characteristics, particularly not sputum characteristics, can guide antibiotic prescription in patients with mild to severe COPD exacerbations https://bit.ly/3e1JV8o.

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Conflict of interest statement

Conflict of interest: P. van Velzen reports grants from Netherlands Organization for Health Research and Development during the conduct of the study. Conflict of interest: G. ter Riet has nothing to disclose. Conflict of interest: P. Brinkman has nothing to disclose. Conflict of interest: P.J. Sterk reports that he is a scientific advisor to and has a formal, inconsiderable interest in the SME Breathomix BV, outside the submitted work. Conflict of interest: J.M. Prins reports grants from Netherlands Organization for Health Research and Development during the conduct of the study.

Figures

FIGURE 1
FIGURE 1
Subgroup analyses for patients who had treatment failure at day 21. Type 1: three Anthonisen criteria [3] present (increased dyspnoea, increased sputum and sputum purulence). Type 2: two Anthonisen criteria present. Type 3: one Anthonisen criterion present. For exacerbation type, sputum purulence and sputum volume, odds ratios differ by an amount that seems clinically relevant. The 95% confidence intervals show that a type II error may be responsible for the large p-value for interaction. GOLD: Global Initiative for Chronic Obstructive Lung Disease; GP: general practitioner.
See this image and copyright information in PMC

References

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