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. 2020 May 5;7(5):ofaa150.
doi: 10.1093/ofid/ofaa150. eCollection 2020 May.

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol

Michael Dagher  1 , Felicia Ruffin  1 , Steven Marshall  2   3   4   5 , Magdalena Taracila  2   3   4   5 , Robert A Bonomo  2   3   4   5 , Rachel Reilly  6 , Vance G Fowler Jr  1 , Joshua T Thaden  1
Affiliations

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol

Michael Dagher et al. Open Forum Infect Dis. .

Abstract

Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to extensively drug-resistant Acinetobacter baumannii. Bacterial whole-genome sequencing identified the strain and antibiotic resistance determinants.

Keywords: Acinetobacter baumannii; antimicrobial resistance; cefiderocol; osteomyelitis.

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Figures

Figure 1.
Figure 1.
Timeline of events. aOutpatient dose gradually increased to 2 g q24H to maintain vancomycin levels of 10–15 mcg/mL. b2.5 mg/kg loading dose then 1.5mg/kg q12H. c8 mg/kg q24H. d2 g q12H. e100 mg loading dose then 50 mg q12H. Abbreviations: AKI, acute kidney injury; Cr, creatinine; ED, emergency department; Pip./Tazo., pipericillin-tazobactam; TMP-SMX, trimethoprim-sulfamethoxazole.
See this image and copyright information in PMC

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