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Comparative Study
. 2020 Oct;36(10):2063-2071.
doi: 10.1007/s10554-020-01904-7. Epub 2020 Jun 3.

Left ventricular mechanical dyssynchrony analzyed by Tc-99m sestamibi SPECT and F-18 FDG PET in patients with ischemic cardiomyopathy and the prognostic value

Yi Tian  1 , Min Zhao  2 , Weilong Li  3 , Ziwei Zhu  1 , Hongzhi Mi  1 , Xiang Li  4 , Xiaoli Zhang  5
Affiliations
Comparative Study

Left ventricular mechanical dyssynchrony analzyed by Tc-99m sestamibi SPECT and F-18 FDG PET in patients with ischemic cardiomyopathy and the prognostic value

Yi Tian et al. Int J Cardiovasc Imaging. 2020 Oct.

Abstract

To compare the left ventricular (LV) phase dyssynchrony parameters obtained from Tc-99m Sestamibi SPECT (GSPECT) and F-18 FDG PET(GPET), as well as the prognostic values in patients with ischemic cardiomyopathy (ICM). Consecutive ICM patients referred for myocardial viability assessment were retrospectively evaluated and were followed-up for 21 ± 5 months. Phase parameter from both GSPECT and GPET were analyzed by QGS software, including histogram bandwidth (BW), standard deviation (SD) and entropy. Independent predictor for cardiac death was analyzed by Cox regression analysis. The estimated cardiac survival curve was analyzed by and was compared with the log-rank test. Eight-eight (mean age 56 ± 10, male 94%, LVEFSPECT23 ± 10%) ICM patients were included for analysis. Moderate correlations were observed for BW (r = 0.65; p < 0.001), SD (r = 0.63; p < 0.001) and entropy (r = 0.73; p < 0.001) between GSPECT and GPET. Among all covariates, the extent of myocardial scar was significantly associated with the differences of SD (r = 0.22; p < 0.05) and entropy (r = - 0.7; p < 0.05), whereas the extent of myocardial viability was not (all p > 0.05). Entropy measured by GSPECT was the predictor for cardiac death (p = 0.037) while QRS duration was not. The cardiac survival of patients with a high entropy (≥ 59%) was significantly lower than that of patients with low entropy (< 59%) (p < 0.05). GSPECT and GPET-derived phase parameters were not interchangeable in ICM patients. Patients with LV dyssynchrony measured by gated SPECT were associated with a worse outcome.

Keywords: Mechanical dyssynchrony; PET; Phase analysis; SPECT.

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References

    1. Chen J, Garcia EV, Bax JJ, Iskandrian AE, Borges-Neto S, Soman P (2011) SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony. J Nucl Cardiol 18(4):685–694. https://doi.org/10.1007/s12350-011-9392-x - DOI - PubMed - PMC
    1. Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, van der Wall EE, Schalij MJ, Garcia EV, Bax JJ (2007) Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? J Nucl Med 48(7):1104–1111. https://doi.org/10.2967/jnumed.107.039925 - DOI - PubMed
    1. Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ (2011) Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy. Circulation 123(1):70–78. https://doi.org/10.1161/CIRCULATIONAHA.110.945345 - DOI - PubMed
    1. Uebleis C, Hellweger S, Laubender RP, Becker A, Sohn HY, Lehner S, Haug A, Bartenstein P, Cumming P, Van Kriekinge SD, Slomka PJ, Hacker M (2012) Left ventricular dyssynchrony assessed by gated SPECT phase analysis is an independent predictor of death in patients with advanced coronary artery disease and reduced left ventricular function not undergoing cardiac resynchronization therapy. Eur J Nucl Med Mol Imaging 39(10):1561–1569. https://doi.org/10.1007/s00259-012-2157-1 - DOI - PubMed
    1. Pazhenkottil AP, Buechel RR, Husmann L, Nkoulou RN, Wolfrum M, Ghadri JR, Kummer J, Herzog BA, Kaufmann PA (2011) Long-term prognostic value of left ventricular dyssynchrony assessment by phase analysis from myocardial perfusion imaging. Heart 97(1):33–37. https://doi.org/10.1136/hrt.2010.201566 - DOI - PubMed

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