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. 2020 Aug;190(3):e141-e143.
doi: 10.1111/bjh.16916. Epub 2020 Jun 28.

Terminal complement inhibition dampens the inflammation during COVID-19

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Terminal complement inhibition dampens the inflammation during COVID-19

Austin G Kulasekararaj et al. Br J Haematol. 2020 Aug.
No abstract available

Keywords: C5 inhibition; COVID-19; complement activation; paroxysmal nocturnal haemoglobinuria.

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References

    1. Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, et al. Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis. MBio. 2018;9(5): e01753‐18. - PMC - PubMed
    1. Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995;333(19):1253–8. - PubMed
    1. Hillmen P, Hall C, Marsh JCW, Elebute M, Bombara MP, Petro BE, et al. Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2004;350(6):552–9. - PubMed
    1. Kulasekararaj AG, Hill A, Rottinghaus ST, Langemeijer S, Wells R, Gonzalez‐Fernandez FA, et al. Ravulizumab (ALXN1210) vs eculizumab in C5‐inhibitor‐experienced adult patients with PNH: the 302 study. Blood. 2019;133(6):540–9. - PMC - PubMed
    1. Risitano AM, Mastellos DC, Huber‐Lang M, Yancopoulou D, Garlanda C, Ciceri F, et al. Complement as a target in COVID‐19? Nat Rev Immunol. 2020;20(6):343–4. - PMC - PubMed

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