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. 1977 Apr;30(4):297-302.
doi: 10.7164/antibiotics.30.297.

Studies on aculeacin. I. Isolation and characterization of aculeacin A

K Mizuno, A Yagi, S Satoi, M Takada, M Hayashi
Free article

Studies on aculeacin. I. Isolation and characterization of aculeacin A

K Mizuno et al. J Antibiot (Tokyo). 1977 Apr.
Free article

Abstract

Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including theonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.

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